ingredientIpilimumab 50 mg
substitutesIpilimumab 50 mg
Shipping classCold chain shipment
Medicine Overview by Anukar Pharmacy
( Yervoy 50mg 1s Injection )
TreatmentYERVOY is indicated for the treatment of advanced (unresectable or metastatic) melanoma in adults.
Side EffectsFatigue, diarrhea, pruritus, rash, colitis, headache, weight loss, nausea, pyrexia, decreased appetite, vomiting, insomnia; immune-mediated reactions; also with nivolumab: musculoskeletal pain, abdominal pain, cough, arthralgia, dyspnea.
Method of UseIt will be administered by a health care professional. Do not shake product. Inspect parenteral drug products visually for particulate matter and discoloration prior to administration. Discard vial if solution is cloudy, there is pronounced discoloration (solution may have pale-yellow color), or there is foreign particulate matter other than translucent-towhite, amorphous particles.
How WorksCTLA-4 is a negative regulator of T-cell activity. Ipilimumab is a monoclonal antibody that binds to CTLA-4 and blocks the interaction of CTLA-4 with its ligands, CD80/CD86. Blockade of CTLA-4 has been shown to augment T-cell activation and proliferation, including the activation and proliferation of tumor infiltrating T-effector cells. Inhibition of CTLA-4 signaling can also reduce T-regulatory cell function, which may contribute to a general increase in T cell responsiveness, including the anti-tumor immune response.
More Info by Anukar Pharmacy
( Yervoy 50mg 1s Injection )
Suggestions
- Severe and fatal immune-mediated adverse reactions can develop. Permanently discontinue therapy and initiate systemic high-dose corticosteroids for severe, persistent, or recurring immune-mediated reactions.
- Withhold dose for moderate immune-mediated adverse reactions until return to baseline, improvement to mild severity, or complete resolution, and patient is receiving <7.5mg prednisone or equivalent per day. Monitor for enterocolitis, hepatitis, dermatitis, neuropathy, endocrinopathy, and others including ocular manifestations; perform clinical chemistries including LFTs, ACTH levels, and thyroid tests at baseline and before each dose.
- Monitor for infusion reactions; discontinue if severe or life-threatening; interrupt or slow infusion rate if mild or moderate.
- Give steroid eye drops if uveitis, iritis, or episcleritis develops (may need systemic treatment if a Vogt-Koyanagi-Harada-like syndrome develops); permanently discontinue if unresponsive to local therapy. Moderate or severe hepatic impairment.
Warning by Anukar Pharmacy
( Yervoy 50mg 1s Injection )
Special precautions for ( Yervoy 50mg 1s Injection ) Heads up
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Alcohol
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There is no significant data. Please consult your doctor. | |
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Pregnancy
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WEIGH RISKS VS BENEFITS | Females of reproductive potential should use effective contraception during and for 3 months after final dose. |
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Lactation
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WEIGH RISKS VS BENEFITS | For Nursing mother it is not recommended |
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Driving
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YERVOY has minor influence on the ability to drive and use machines. Because of potential adverse reactions such as fatigue (see section 4.8), patients should be advised to use caution when driving or operating machinery until they are certain that ipilimumab does not adversely affect them. | |
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Kidney
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There is no significant data. Please consult your doctor. | |
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Liver
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There is no significant data. Please consult your doctor. |
Suggestion by Anukar Pharmacy on missing a dose
( Yervoy 50mg 1s Injection )
If you miss a dose of Yervoy, please contact your doctor.
Disclaimer
The information of Anukar Pharmacy is for reference purpose only, and Anukar Pharmacy or Anukar Pharmacy or Anukar Pharmacy is not intended to be a replacement of professional medical advice, diagnosis, or treatment. Anukar Pharmacy suggest to ask the advice of a physician or any qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of anything you have learned from Anukar Pharmacy.